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Hydrogen & its Role in
Neurological Disorders

Hydrogen & Neurological Disorders

Neurological Disorders
Oxidative stress and neuroinflammation cause many neurological disorders. H2 use has been extensively researched for neurological disorders, such as cerebrovascular diseases, neurodegenerative disorders, and neonatal brain disorders. Although most neurological disorders are currently incurable, some studies suggest the clinical potential of H2 administration for their prevention, treatment, and mitigation.
Cerebovascular Disease
Ohsawa et al. were the first to report that inhalation of H2 gas markedly suppresses rat brain injury induced by focal ischemia-reperfusion by buffering oxidative stress, as assessed by the accumulation of its markers 8-hydroxyl-2′-deoxyguanosine (8-OHdG) and 4-hydroxynonenal (4-HNE). Surprisingly, treatment with H2 gas is more effective than that with edaravone, which is an ROS scavenger and used in the treatment of cerebral infarction.
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Nagatani et al. reported that inhalation of H2 gas improves the survival rate of mice from 8.3% to 50% following global cerebral IRI by bilateral common carotid artery occlusion.
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Neurodegenerative Disorders
Aging is associated with an increase in the incidence of neurodegenerative disorders, creating a large problem that needs to be solved in our aging society. Oxidative stress and inflammation are leading causes of PD (Parkinsons Disease), AD (Alzheimer Disease) and other neurodegenerative disorders. Many studies indicate that H2 treatment is potentially useful for alleviating neurodegenerative disorders and improving the quality of life in senior people.
Recently, a randomized double-blind placebo-controlled pilot study was conducted to investigate the therapeutic efficacy of HW (Hydrogen Water) in patients with PD. Participants drank 1 litre per day of HW or pseudo-water for 48 weeks. The Total Unified Parkinson’s Disease Rating Scale scores in the HW group improved, whereas scores in the placebo group worsened.
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Neurodegenerative Disorders
Aging is associated with an increase in the incidence of neurodegenerative disorders, creating a large problem that needs to be solved in our aging society. Oxidative stress and inflammation are leading causes of PD (Parkinsons Disease), AD (Alzheimer Disease) and other neurodegenerative disorders. Many studies indicate that H2 treatment is potentially useful for alleviating neurodegenerative disorders and improving the quality of life in senior people.
Recently, a randomized double-blind placebo-controlled pilot study was conducted to investigate the therapeutic efficacy of HW (Hydrogen Water) in patients with PD. Participants drank 1 litre per day of HW or pseudo-water for 48 weeks. The Total Unified Parkinson’s Disease Rating Scale scores in the HW group improved, whereas scores in the placebo group worsened.
Read More